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Bioorg Med Chem Lett. 2007 Feb 15;17(4):974-7. Epub 2006 Nov 17.

Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.

Author information

1
Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5100, Wallingford, CT 06492-7660, USA. mark.wittman@bms.com

Abstract

A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.

PMID:
17187980
DOI:
10.1016/j.bmcl.2006.11.041
[Indexed for MEDLINE]

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