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Developmental toxic effects of antifungal flusilazole administered by gavage to mice.

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1
Department of Pesticide Chemistry and Toxicology, Faculty of Agriculture, Alexandria University, Egypt. aminafarag2002@yahoo.com

Abstract

BACKGROUND:

The developmental toxicity of flusilazole was studied in CD-1 mice after oral administration.

METHODS:

Pregnant mice were given flusilazole at doses of 0 (corn oil), 10, 20, and 40 mg/kg/day, by gavage, on gestational days (GD) 6-15.

RESULTS:

Maternal toxicity, as evidenced by reduction in body weight gain and signs of toxicity, was observed at the middle- and high-dose groups. No significant incidence of resorptions or death was observed in any of dose groups. There was a pronounced reduction in fetal weight, which was significantly lower than control from 20 and 40 mg/kg/day. There was no significant increase in the incidence of fetuses with external or visceral malformations in any of dose groups, but there was a significant increase in the incidence of skeletal malformations was observed at 20 and 40 mg/kg/day.

CONCLUSIONS:

The results of this study reported marked maternal toxicity, growth retardation, and skeletal abnormalities in the mid- and high-dose groups. It seems likely that marked maternal toxicity contributed to the observed alterations in fetal growth retardation and skeletal development. The no-observed-effect level in the present study for maternal and developmental toxicity was 10 mg/kg/day.

PMID:
17187383
DOI:
10.1002/bdrb.20098
[Indexed for MEDLINE]
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