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Nat Rev Immunol. 2007 Jan;7(1):52-63.

Regulation of immune tolerance by anti-inflammatory neuropeptides.

Author information

1
Instituto de Parasitología y Biomedicina, Consejo Superior de Investigaciones Cientificas, Avenida Conocimiento, Parque Tecnológico de Ciencias de la Salud, Granada 18100, Spain.

Abstract

The induction of antigen-specific tolerance is essential to maintain immune homeostasis, control autoreactive T cells, prevent the onset of autoimmune diseases and achieve tolerance of transplants. Inflammation is a necessary process for eliminating pathogens, but can lead to serious deleterious effects in the host if left unchecked. Identifying the endogenous factors that control immune tolerance and inflammation is a key goal in the field of immunology. In the last decade, various neuropeptides that are produced by immune cells with potent anti-inflammatory actions were found to participate in the maintenance of tolerance in different immunological disorders.

PMID:
17186031
DOI:
10.1038/nri1984
[Indexed for MEDLINE]
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