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Gastrointest Endosc. 2007 Jan;65(1):134-9.

Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors.

Author information

1
Developmental Endoscopy Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

Abstract

BACKGROUND:

A flexible needle-catheter tissue-anchoring device was developed to accomplish full-thickness tissue apposition of the GI wall. The aim of this study was to identify the performance of this device for repair of large iatrogenic gastric perforations in a porcine model.

OBJECTIVES:

Six pigs.

DESIGN:

Short-term survival animal study.

SETTINGS:

Pigs were studied while they were under general anesthesia. Device performance in differing gastric locations and wall thicknesses was assessed by 2 perforations more than 2 cm in size created for each pig along the greater curvature and the anterior wall.

INTERVENTIONS:

Each perforation was closed by parallel placement of tissue anchor sets sequentially along the length of the perforation.

MAIN OUTCOME MEASUREMENTS:

One week follow-up endoscopy and necropsy were performed.

RESULTS:

Twelve perforations were closed with the 48 tissue anchor sets. All animals survived for 1 week without clinical complications. Follow-up endoscopy and necropsy revealed that all tissue anchors remained with firmly held sutures and sealed perforations.

CONCLUSIONS:

Full-thickness closure with a new tissue-anchoring device simply and successfully repaired large iatrogenic gastric perforations.

PMID:
17185093
DOI:
10.1016/j.gie.2006.01.050
[Indexed for MEDLINE]

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