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PLoS One. 2006 Dec 20;1:e79.

Mesenchymal stem cell-mediated functional tooth regeneration in swine.

Author information

1
Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, California, United States of America; Department of Oral and Maxillofacial Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Abstract

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

PMID:
17183711
PMCID:
PMC1762318
DOI:
10.1371/journal.pone.0000079
[Indexed for MEDLINE]
Free PMC Article

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