Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2006 Dec 20;1:e2.

Allometric scaling of the active hematopoietic stem cell pool across mammals.

Author information

1
Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America. dingli@fas.harvard.edu

Abstract

BACKGROUND:

Many biological processes are characterized by allometric relations of the type Y = Y(0)M(b) between an observable Y and body mass M, which pervade at multiple levels of organization. In what regards the hematopoietic stem cell pool, there is experimental evidence that the size of the hematopoietic stem cell pool is conserved in mammals. However, demands for blood cell formation vary across mammals and thus the size of the active stem cell compartment could vary across species.

METHODOLOGY/PRINCIPLE FINDINGS:

Here we investigate the allometric scaling of the hematopoietic system in a large group of mammalian species using reticulocyte counts as a marker of the active stem cell pool. Our model predicts that the total number of active stem cells, in an adult mammal, scales with body mass with the exponent 3/4.

CONCLUSION/SIGNIFICANCE:

The scaling predicted here provides an intuitive justification of the Hayflick hypothesis and supports the current view of a small active stem cell pool supported by a large, quiescent reserve. The present scaling shows excellent agreement with the available (indirect) data for smaller mammals. The small size of the active stem cell pool enhances the role of stochastic effects in the overall dynamics of the hematopoietic system.

PMID:
17183646
PMCID:
PMC1762381
DOI:
10.1371/journal.pone.0000002
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center