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Nat Rev Neurosci. 2007 Jan;8(1):45-56.

Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks.

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1
Physiologisches Institut der Universit├Ąt Freiburg, Abteilung 1, Hermann Herder Strasse 7, D-79104 Freiburg, Germany.

Abstract

Gamma frequency oscillations are thought to provide a temporal structure for information processing in the brain. They contribute to cognitive functions, such as memory formation and sensory processing, and are disturbed in some psychiatric disorders. Fast-spiking, parvalbumin-expressing, soma-inhibiting interneurons have a key role in the generation of these oscillations. Experimental analysis in the hippocampus and the neocortex reveals that synapses among these interneurons are highly specialized. Computational analysis further suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators.

PMID:
17180162
DOI:
10.1038/nrn2044
[Indexed for MEDLINE]
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