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Eur J Clin Nutr. 2007 May;61(5):686-9. Epub 2006 Dec 20.

Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients.

Author information

1
Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Abstract

OBJECTIVE:

To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone.

DESIGN:

Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin.

SETTING:

General Clinical Research Center at Vanderbilt University Medical Center.

SUBJECTS:

Five chronic hemodialysis (CHD) patients.

INTERVENTIONS:

Intra-dialytic parenteral nutrition (IDPN) with or without exercise.

RESULTS:

Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2+/-3.1% per day versus 17.7+/-1.9% per day, P<0.05).

CONCLUSION:

Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients.

PMID:
17180156
DOI:
10.1038/sj.ejcn.1602578
[Indexed for MEDLINE]

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