Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Clin Pract Cardiovasc Med. 2007 Jan;4(1):42-50.

Drug insight: aspirin resistance--fact or fashion?

Author information

1
University of Rome La Sapienza, Ospedale Sant'Andrea, Via di Grottarossa 1035, 00189 Rome, Italy. cpatrono@unich.it

Abstract

The term aspirin resistance has been used increasingly in clinical studies. The aim of this Review is to analyze the origin of this term, to discuss the biochemical, functional and clinical correlates of the phenomenon and to offer a conceptual framework to redefine the major determinants of variability between individuals in response to aspirin. Awareness needs to be increased of factors that might interfere with the desired antiplatelet effect of aspirin, particularly in terms of patients' adherence to treatment and avoidable drug interactions with some traditional NSAIDs. Gaining such knowledge could result in improved care of patients and might avoid the requesting of unnecessary platelet function tests of unproven clinical significance.

Comment in

PMID:
17180149
DOI:
10.1038/ncpcardio0728
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center