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Antimicrob Agents Chemother. 2007 Mar;51(3):1099-101. Epub 2006 Dec 18.

Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.

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1
School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959, Australia. tdavis@cyllene.uwa.edu.au

Abstract

The effect of mefloquine on artesunate pharmacokinetics was assessed in 20 volunteers given artesunate for 3 days, followed > or =21 days later by combination therapy for 3 days. The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction.

PMID:
17178798
PMCID:
PMC1803145
DOI:
10.1128/AAC.01253-06
[Indexed for MEDLINE]
Free PMC Article
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