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Infect Immun. 2007 Mar;75(3):1520-3. Epub 2006 Dec 18.

c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection.

Author information

1
Department of Microbiology and Immunology, School of Medicine, Keio University, 160-8582 Tokyo, Japan.

Abstract

c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-kappaB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.

PMID:
17178788
PMCID:
PMC1828558
DOI:
10.1128/IAI.01316-06
[Indexed for MEDLINE]
Free PMC Article

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