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Mol Genet Metab. 2007 Apr;90(4):358-62. Epub 2006 Dec 18.

The functions of RPS19 and their relationship to Diamond-Blackfan anemia: a review.

Author information

1
Division of Hematology/Oncology, Department of Pediatrics, UCLA Mattel Children's Hospital, CA 90095, USA. kmorimoto@mednet.ucla.edu

Abstract

The relatively new study of ribosomal proteins has allowed for greater understanding of protein synthesis; however the connection between ribosomal proteins' roles and that of disease pathophysiology has not yet been established. RPS19 is a ribosomal protein linked to Diamond-Blackfan anemia whose functions have begun to be elucidated. We review here the known roles of RPS19 in both ribosome construction and other extra-ribosomal functions and discuss their relationship to Diamond-Blackfan anemia.

PMID:
17178250
DOI:
10.1016/j.ymgme.2006.11.004
[Indexed for MEDLINE]

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