Format

Send to

Choose Destination
Nutr Cancer. 2006;56(1):82-5.

Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats.

Author information

1
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Rutgers-The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA. florek@rci.rutgers.edu

Abstract

Gamma (gamma) tocopherol, but not alpha (alpha) tocopherol (vitamin E), has previously been reported as an effective inhibitor of cyclooxygenase (COX) enzyme activity. In a pilot study of 17 rats, mixed tocopherols containing more than 50% gamma-tocopherol, added at 0.1% to an AIN-76A diet, produced a significant inhibition (about 55%) of azoxymethane-induced aberrant crypt foci in the colon of rats. Mixed tocopherols also reduced tetradecanoyl phorbol acetate-induced ear inflammation in mice when topically applied.

PMID:
17176221
DOI:
10.1207/s15327914nc5601_11
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center