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Curr Biol. 2006 Dec 19;16(24):R1030-2.

Chemotaxis: Cofilin in the driver's seat.

Author information

1
Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, New Jersey 08854-8021, USA. hitchcoc@umdnj.edu

Abstract

A cell responds to a chemotactic signal by activating actin polymerization and forming a protrusion oriented towards the source. Recent work shows that the activity of cofilin, a protein that creates new barbed ends for actin filament elongation, amplifies and specifies the direction of the response in carcinoma cells.

PMID:
17174909
DOI:
10.1016/j.cub.2006.11.011
[Indexed for MEDLINE]
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