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Cell. 2006 Dec 15;127(6):1093-5.

A view to a kill: structure of the RNA exosome.

Author information

1
Rutgers University, Department of Cell Biology and Neuroscience, 604 Allison Road, Piscataway, NJ 08854, USA.

Abstract

The exosome is a 3' to 5' exoribonuclease central to many cellular processes, including mRNA decay. now present the biochemical reconstitution and crystal structure of the eukaryotic exosome. This remarkable achievement provides key insights into the composition and assembly of the human and yeast exosomes, revealing functions of individual subunits.

PMID:
17174886
PMCID:
PMC1986773
DOI:
10.1016/j.cell.2006.11.035
[Indexed for MEDLINE]
Free PMC Article

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