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Methods Mol Biol. 2007;364:215-30.

Automated structure solution with autoSHARP.

Author information

1
Global Phasing Ltd., Sheraton House, Castle Park, Cambridge, UK.

Abstract

We present here the automated structure solution pipeline "autoSHARP." It is built around the heavy-atom refinement and phasing program SHARP, the density modification program SOLOMON, and the ARP/wARP package for automated model building and refinement (using REFMAC). It allows fully automated structure solution, from merged reflection data to an initial model, without any user intervention. We describe and discuss the preparation of the user input, the data flow through the pipeline, and the various results obtained throughout the procedure.

PMID:
17172768
DOI:
10.1385/1-59745-266-1:215
[Indexed for MEDLINE]

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