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Methods Mol Biol. 2007;361:299-309.

Considerations for target validation and industrial approaches.

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Global External Research and Development, Lilly Research Laboratories, Lilly Corporate Centre, Indianapolis, IN, USA.


Target validation in health and disease integrates the modulation of a certain molecular target with an expected biological/biochemical/physiological or pathophysiological response or effect. The current state-of-the-art in target validation requires the interface of multiple complementary approaches and technologies to define the mechanistic connectivity between a molecular target and underlying micro- and macrobiotic processes. Target validation also represents the basis for "drug target validation" with focus on therapeutic applications. The concepts of "target validation" and "drug-based therapeutic intervention" continue to coevolve as new classes of therapeutic agents and delivery systems emerge and enable us to target or modulate previously inaccessible molecular entities.

[Indexed for MEDLINE]

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