Format

Send to

Choose Destination
Nat Rev Immunol. 2007 Jan;7(1):64-75. Epub 2006 Dec 15.

Notch signalling during peripheral T-cell activation and differentiation.

Author information

1
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA. Osborne@vasci.umass.edu

Abstract

For many years, researchers have focused on the contribution of Notch signalling to lymphoid development. Only recently have investigators begun to ask what role, if any, Notch has during the activation and differentiation of naive CD4(+) T cells in the periphery. As interest in this issue grows, it is becoming increasingly clear that the main role of Notch signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells.

PMID:
17170755
DOI:
10.1038/nri1998
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center