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Curr Opin Chem Biol. 2007 Feb;11(1):74-82. Epub 2006 Dec 13.

A pipeline for ligand discovery using small-molecule microarrays.

Author information

1
Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

Uncovering the functions of thousands of gene products, in various states of post-translational modification, is a key challenge in the post-genome era. To identify small-molecule probes for each protein function, high-throughput methods for ligand discovery are needed. In recent years, small-molecule microarrays (SMMs) have emerged as high-throughput and miniaturized screening tools for discovering protein-small-molecule interactions. Microarrays of small molecules from a variety of sources, including FDA-approved drugs, natural products and products of combinatorial chemistry and diversity-oriented synthesis, have been prepared and screened by several laboratories, leading to several newly discovered protein-ligand pairs.

PMID:
17169601
DOI:
10.1016/j.cbpa.2006.11.031
[Indexed for MEDLINE]

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