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Trends Cell Biol. 2007 Feb;17(2):72-9. Epub 2006 Dec 13.

HMG chromosomal proteins in development and disease.

Author information

1
Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany. rhock@biozentrum.uni-wuerzburg.de <rhock@biozentrum.uni-wuerzburg.de>

Abstract

The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber. They are important in chromatin dynamics and influence DNA processing in the context of chromatin. Results emerging from studies of human disease, genetically modified mice and cells with altered HMG expression indicate that the expression of the HMG proteins is developmentally regulated and that changes in HMG protein levels alter the cellular phenotype and can lead to developmental abnormalities and disease. Here, we focus on the biological function of HMG proteins and highlight their possible roles in cellular differentiation and in the etiology of various diseases.

PMID:
17169561
PMCID:
PMC2442274
DOI:
10.1016/j.tcb.2006.12.001
[Indexed for MEDLINE]
Free PMC Article

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