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Mini Rev Med Chem. 2006 Dec;6(12):1299-309.

Carbohydrate-based scaffolds in drug discovery.

Author information

1
Alchemia Ltd, PO Box 6242, Upper Mt Gravatt, Qld 4122, Australia. bbecker@alchemia.com.au

Abstract

Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.

PMID:
17168806
[Indexed for MEDLINE]

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