Synthesis of tetrahydrobenzimidazo[1,2-b]quinazolin-1(2H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one ring systems under solvent-free conditions

Comb Chem High Throughput Screen. 2006 Dec;9(10):771-6. doi: 10.2174/138620706779026060.

Abstract

Tetraheterocyclic benzimidazo[1,2-a]quinazolin-4(1H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one were synthesized in relatively high yields by the condensation reaction of an aldehyde and a cyclic beta-diketone with 2-aminobenzothiazole, 2-aminobenzimidazole or 3-amino-1,2,4-triazole without using any catalyst under solvent-free conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Amitrole / chemistry*
  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / chemistry*
  • Combinatorial Chemistry Techniques / methods*
  • Molecular Structure
  • Quinazolines / chemical synthesis*
  • Quinazolines / chemistry*
  • Solvents / chemistry
  • Triazoles / chemical synthesis*
  • Triazoles / chemistry

Substances

  • Aldehydes
  • Benzimidazoles
  • Quinazolines
  • Solvents
  • Triazoles
  • 2-aminobenzimidazole
  • Amitrole