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Vaccine. 1991 Jul;9(7):470-2.

Overcoming inhibition of antibody responses to a malaria recombinant vaccinia virus caused by prior exposure to wild type virus.

Author information

1
Central Research Units, F. Hoffman-La Roche Ltd., Basel, Switzerland.

Abstract

Pre-injection of mice with vaccinia virus inhibited the subsequent antibody response to a recombinant polypeptide expressed by vaccinia virus. The inhibition was overcome following additional challenges with recombinant vaccinia virus. This suggests that a potential disadvantage in vaccinia-immune individuals can be circumvented and may be outweighed by the advantages of the vector.

PMID:
1716807
DOI:
10.1016/0264-410x(91)90030-a
[Indexed for MEDLINE]

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