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Gene Ther. 2007 Jan;14(2):99-107. Epub 2006 Nov 30.

Gene therapy progress and prospects: hydrodynamic gene delivery.

Author information

1
Mirus Bio Corporation, Madison, WI, USA.

Abstract

Over the last few years, hydrodynamic tail vein delivery has established itself as a simple, yet very effective method for gene transfer into small rodents. Hydrodynamic delivery of plasmid DNA expression vectors or small interfering RNA allows for a broad range of in vivo experiments, including the testing of regulatory elements, antibody generation, evaluation of gene therapy approaches, basic biology and disease model creation (non-heritable transgenics). The recent development of the hydrodynamic limb vein procedure provides a safe nucleic acid delivery technique with equally high efficiency in small and large research animals and, importantly, the prospects for clinical translation.

PMID:
17167496
DOI:
10.1038/sj.gt.3302891
[Indexed for MEDLINE]

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