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FEMS Microbiol Lett. 2007 Feb;267(2):207-13. Epub 2006 Dec 8.

Identification of a Moraxella catarrhalis gene that confers adherence to various human epithelial cell lines in vitro.

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Department of Medical Microbiology and Immunology, Medical University of Ohio, Toledo, OH 43614, USA.

Abstract

Moraxella catarrhalis is a pathogen of the human airways. We found that expression of the M. catarrhalis gene mcmA by Escherichia coli increases adherence to epithelial cells 100-fold. Furthermore, we discovered that disrupting mcmA decreases M. catarrhalis adherence to laryngeal and lung cells, which are relevant to pathogenesis by the bacterium.

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