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Trends Biochem Sci. 1991 Jun;16(6):214-20.

RNA recognition: towards identifying determinants of specificity.

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Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.


Members of a family of proteins containing a conserved approximately 80-amino acid RNA recognition motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in combination with sequence alignments, indicate the structural context of both conserved and non-conserved elements in the motif. These analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.

[Indexed for MEDLINE]

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