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Trends Biochem Sci. 1991 Jun;16(6):214-20.

RNA recognition: towards identifying determinants of specificity.

Author information

1
Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.

Abstract

Members of a family of proteins containing a conserved approximately 80-amino acid RNA recognition motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in combination with sequence alignments, indicate the structural context of both conserved and non-conserved elements in the motif. These analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.

PMID:
1716386
DOI:
10.1016/0968-0004(91)90088-d
[Indexed for MEDLINE]

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