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Clin Chem Lab Med. 2006;44(12):1472-80.

Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodies.

Author information

1
Innogenetics NV, Industriepark Zwijnaarde 7, 9052 Gent, Belgium. hugovdr@innogenetics.be

Abstract

BACKGROUND:

Total tau (T-tau) and beta-amyloid((1-42)) (Abeta(1-42)) levels in cerebrospinal fluid (CSF) can differentiate Alzheimer's disease (AD) from normal aging or depressive pseudo-dementia. Differential diagnosis from dementia with Lewy bodies (DLB) in clinical settings is difficult.

METHODS:

The analytical performance of the INNOTEST PHOSPHO-TAU(181P) assay was validated in terms of selectivity, sensitivity, specificity, precision, robustness, and stability. Clinical utility of the assay alone, or combined with T-tau and Abeta(1-42), for discrimination of AD (n=94) from patients suffering from DLB (n=60) or from age-matched control subjects (CS) (n=60) was assessed in a multicenter study.

RESULTS:

CSF concentrations of tau phosphorylated at threonine 181 (P-tau(181P)) in AD was significantly higher than in DLB and CS. Discriminant analysis, a classification tree, and logistic regression showed that P-tau(181P) was the most statistically significant single variable of the three biomarkers for discrimination between AD and DLB.

CONCLUSIONS:

P-tau(181P) quantification is a robust and reliable assay that may be useful in discriminating AD from DLB.

PMID:
17163825
DOI:
10.1515/CCLM.2006.258
[Indexed for MEDLINE]

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