Format

Send to

Choose Destination
Clin Chem Lab Med. 2006;44(12):1428-32.

Point-of-care C-reactive protein testing in febrile children in general practice.

Author information

1
Department of General Practice, Erasmus MC, 3000 CA Rotterdam, The Netherlands.

Abstract

BACKGROUND:

Point-of-care testing for C-reactive protein (CRP) may be helpful in differentiating viral from bacterial infection. Such a device should give results comparable to laboratory testing. The aim was to evaluate two point-of-care CRP tests (Nycocard and QuikRead) in febrile children in general practice, compared to a reference immunoturbidimetric assay.

METHODS:

A cross-sectional study was carried out of febrile children aged 3 months to 6 years presented to a general practice out-of-hours service. Children were visited at home where blood was taken for tests, within 24 h after presentation. The Nycocard test was performed at home, whereas the QuikRead and reference test were performed in the laboratory.

RESULTS:

A total of 76 children were enrolled. All three CRP tests were performed in 59 children. The mean difference between the reference test and Nycocard and QuikRead was 0.6 and -6.1 mg/L, respectively. The slope of the Passing-Bablok regression was 0.95 (95% CI 0.9-1.0) and 0.83 (95% CI 0.81-0.85) for the Nycocard and QuikRead tests, respectively.

CONCLUSIONS:

Up to a concentration of 160 mg/L, the Nycocard test correlated well with the reference test, while the QuikRead test underestimated concentrations above 60 mg/L. The Nycocard test seems a good candidate for CRP point-of-care testing in general practice.

PMID:
17163818
DOI:
10.1515/CCLM.2006.270
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Sheridan PubFactory
Loading ...
Support Center