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ACS Chem Biol. 2006 May 23;1(4):207-10.

Act globally, think locally: systems biology addresses the PDZ domain.

Author information

1
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA. mspaller@chem.wayne.edu

Erratum in

  • ACS Chem Biol. 2010 Jul 16;5(7):713.

Abstract

Interaction networks, cartography and mapping, wiring and circuitry, whichever metaphor is invoked, the cardinal questions regarding cellular proteins are the same: What are they? How much is there? What do they do, and to whom do they do it? One of the more recent proteomics tools to pursue these lines of inquiry is the protein microarray, and a current report has unleashed this formidable technique upon a target of considerable biological interest, the PDZ domain family of signaling molecules.

PMID:
17163673
DOI:
10.1021/cb600191y
[Indexed for MEDLINE]

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