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ACS Chem Biol. 2006 Feb 17;1(1):17-9.

Stopping trouble before it starts.

Author information

1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA. jon_clardy@hms.harvard.edu

Abstract

A recent publication revealing that the cytotoxic marine natural product pateamine A targets eukaryotic initiation factor eIF4A continues a story with lessons for both chemists and biologists, that is, the significance of natural products, the importance of synthetic organic chemistry, the small molecule regulation of eukaryotic translation machinery, and possibly a new approach to cancer chemotherapy.

PMID:
17163634
DOI:
10.1021/cb0600029
[Indexed for MEDLINE]
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