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Semin Cell Dev Biol. 2007 Feb;18(1):117-31. Epub 2006 Nov 24.

Re-employment of developmental transcription factors in adult heart disease.

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1
Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Abstract

A finite number of transcription factors constitute a combinatorial code that orchestrates cardiac development and the specification and differentiation of myocytes. Many, if not all of these same transcription factors are re-employed in the adult heart in response to disease stimuli that promote hypertrophic enlargement and/or dilated cardiomyopathy, as part of the so-called "fetal gene program". This review will discuss the transcription factors that regulate the hypertrophic growth response of the adult heart, with a special emphasis on those regulators that participate in cardiac development.

PMID:
17161634
PMCID:
PMC1855184
DOI:
10.1016/j.semcdb.2006.11.012
[Indexed for MEDLINE]
Free PMC Article
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