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Am J Surg. 2006 Dec;192(6):882-7.

Prediction of sentinel lymph node-only disease in women with invasive breast cancer.

Author information

  • 1Department of Surgery, University of Louisville, 315 East Broadway, Suite 312, Louisville, KY 40202, USA. anees.chagpar@nortonhealthcare.org <anees.chagpar@nortonhealthcare.org>

Abstract

BACKGROUND:

The purpose of this study was to create a model that predicts which breast cancer patients will have sentinel lymph node (SLN)-only metastasis.

METHODS:

SLN-positive breast cancer patients (N = 1,253) were analyzed. Multivariate analysis was performed to identify factors predicting SLN-only disease; a prediction rule was created.

RESULTS:

Median tumor size was 2 cm. The median number of SLNs removed was 2; the median number of positive SLNs was 1. Multivariate analysis found tumor size, number of positive SLN, and proportion of SLN positive were significant predictors of SLN-only disease (P < .001). A prediction rule with 1 point being given for >1 positive SLN, 1 point for >50% of SLN positive, and up to 4 points for tumor size (T1a = 1, T1b or T1c = 2, T2 = 3, and T3 = 4) was established. Ninety-five percent of patients with 1 point had SLN-only disease (P < .0001).

CONCLUSION:

An integer-based model may predict SLN-only disease and may be useful in determining whether completion axillary lymph node dissection is required.

PMID:
17161113
DOI:
10.1016/j.amjsurg.2006.08.063
[PubMed - indexed for MEDLINE]
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