Format

Send to

Choose Destination
Nat Rev Drug Discov. 2007 Jan;6(1):56-65. Epub 2006 Dec 8.

Waltzing transporters and 'the dance macabre' between humans and bacteria.

Author information

1
Mpex Pharmaceuticals, Inc. 3030 Bunker Hill Street, Suite 200 San Diego, California 92109, USA. olomovskaya@mpexpharma.com

Abstract

Multidrug-resistance efflux pumps - in particular those belonging to the resistance-nodulation-cell-division (RND) family of transporters, with their unusually high degree of substrate promiscuity - significantly restrict the effectiveness of antibacterial therapy. Recent years have heralded remarkable insights into the structure and mechanisms of these fascinating molecular machines. Here, we review recent advances in the field and describe various approaches used in combating efflux-mediated resistance.

PMID:
17159924
DOI:
10.1038/nrd2200
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center