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Arch Ophthalmol. 2006 Dec;124(12):1711-8.

Longitudinal postnatal weight and insulin-like growth factor I measurements in the prediction of retinopathy of prematurity.

Author information

1
Göteborg Pediatric Growth Research Center, Department of Pediatrics, Institute of the Health of Women and Children, Göteborg University, Göteborg, Sweden.

Erratum in

  • Arch Ophthalmol. 2007 Mar;125(3):426.

Abstract

OBJECTIVE:

To investigate whether postnatal growth and development influence retinopathy of prematurity (ROP) and may be included in screening for ROP.

DESIGN:

We developed an algorithm to predict for individual infants the risk of later ROP development requiring treatment based on the postnatal longitudinal systemic factors of insulin-like growth factor I (IGF-I) level, IGF binding protein 3 level, and postnatal weight gain. We developed the algorithm based on 79 preterm infants considered at risk for ROP by standard criteria (gestational age, 23.6-31.7 weeks) in a longitudinal study measuring weight gain and serum IGF-I and IGF binding protein 3 levels weekly from birth until discharge from the hospital. We monitored deviations from reference models for weight and IGF-I level (preterm children who developed no or minimal ROP) to detect indications for treatable ROP by Early Treatment for Retinopathy of Prematurity study criteria.

RESULTS:

This monitoring method detected 6 (100%) of 6 infants in this cohort who required treatment for ROP with a warning signal at least 5 weeks before requiring treatment and at least 3 weeks before the onset of stage 3 ROP. The majority of infants (61/73 infants) requiring no treatment were also correctly identified.

CONCLUSIONS:

Monitoring the postnatal factors of weight, IGF-I level, and IGF binding protein 3 level substantially enhances the clinician's ability to identify patients who will require treatment for ROP.

PMID:
17159030
DOI:
10.1001/archopht.124.12.1711
[Indexed for MEDLINE]

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