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Infect Immun. 2007 Mar;75(3):1517-9. Epub 2006 Dec 11.

Rapid clearance of Lyme disease spirochetes lacking OspC from skin.

Author information

  • 1Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA. ktilly@niaid.nih.gov

Abstract

We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.

PMID:
17158906
PMCID:
PMC1828573
DOI:
10.1128/IAI.01725-06
[PubMed - indexed for MEDLINE]
Free PMC Article
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