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J Bacteriol. 2007 Mar;189(5):2114-8. Epub 2006 Dec 8.

Amino acid residues required for maturation, cell uptake, and processing of translation inhibitor microcin C.

Author information

1
Waksman Institute, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Abstract

Microcin C (McC), a peptide-nucleotide Trojan horse antibiotic, targets aspartyl-tRNA synthetase. We present the results of a systematic mutational study of the 7-amino-acid ribosomally synthesized peptide moiety of McC. Our results define amino acid positions important for McC maturation and cell uptake and processing and open the way for creation of more potent McC-based inhibitors.

PMID:
17158672
PMCID:
PMC1855700
DOI:
10.1128/JB.01609-06
[Indexed for MEDLINE]
Free PMC Article

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