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Cancer Cell. 2006 Dec;10(6):454-6.

Radiation resistance and stem-like cells in brain tumors.

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  • 1Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Erratum in

  • Cancer Cell. 2007 Jan;11(1):97. Squartro, Massimo [corrected to Squatrito, Massimo].


The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding to therapy followed by recurrence are well documented. On this foundation, a recent paper in Nature has demonstrated that CD133-expressing glioma cells in vivo and in culture are relatively resistant to radiation. The mechanism of resistance involves the cell-cycle-regulating proteins CHK1/CHK2. The data raise many questions about the details of radiobiology of stem-like cells in their native environment within tumors in vivo. These answers may lead to better optimization of radiation treatments and schedules for these patients.

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