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Curr Opin Immunol. 2007 Feb;19(1):66-72. Epub 2006 Dec 6.

Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules.

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Cancer Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.


Cross-presentation of exogenous proteins on MHC class I complexes contributes to the priming CD8(+) T-cell responses. However, the mechanisms by which antigen-presenting cells transfer internalized proteins to the MHC class I loading pathway are not well understood. Endocytosed proteins often appear to require proteasomal processing and transport into the endoplasmic reticulum, but the intracellular routes involved in cross-presentation remain unclear. Understanding the molecular and cellular basis of cross-presentation will illuminate novel aspects of cell physiology and might lead to improved vaccine design.

[Indexed for MEDLINE]

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