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Eur J Obstet Gynecol Reprod Biol. 2008 Jan;136(1):110-5. Epub 2006 Dec 8.

Prognostic value of nuclear DNA quantification and cyclin A expression in epithelial ovarian carcinoma.

Author information

1
Department of Obstetrics and Gynecology, Women's Cancer Clinic, Yonsei University College of Medicine, Seoul, Republic of Korea.

Abstract

OBJECTIVE:

To investigate the correlation of DNA ploidy, S-phase fraction (SPF) and the expression of cyclin A to the clinical prognostic factors in patients with epithelial ovarian cancer.

STUDY DESIGN:

A prospective analysis was performed on 46 ovarian tumor patients. The DNA ploidy and SPF were determined by flow cytometry and the expression of cyclin A was measured by immunohistochemical staining.

RESULTS:

Compared with benign and borderline tumors, the malignant tumors expressed higher levels of cyclin A (P=0.007), more aneuploid cells (P=0.018) and higher SPF (P=0.015). With regard to DNA ploidy and the clinical prognostic factors, aneuploid cells increased with tumor grade (P=0.011), the disease stage (P=0.009) and residual volume (P=0.001). When residual tumor was more than 2 cm, the expression of cyclin A was increased (P=0.043). Three-year survival was low for patients with tumors expressing cyclin A in over 10% of cells (P=0.003).

CONCLUSIONS:

The data suggest that the assessment of the DNA ploidy, SPF and the expression of cyclin A may provide important information for predicting the prognosis of epithelial ovarian cancer.

PMID:
17157431
DOI:
10.1016/j.ejogrb.2006.10.008
[Indexed for MEDLINE]

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