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Transpl Immunol. 2006 Dec;17(1):58-60. Epub 2006 Oct 10.

Tryptophan catabolism generates autoimmune-preventive regulatory T cells.

Author information

1
Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy. fllfnc@tin.it

Abstract

Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4(+)CD25(-) cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.

PMID:
17157218
DOI:
10.1016/j.trim.2006.09.017
[Indexed for MEDLINE]

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