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Trends Biochem Sci. 1991 May;16(5):170-1.

Tandem sequence repeats in transmembrane channel proteins.

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  • 1Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892.


The flow of ions and small molecules out of and between cells is mediated by various classes of transmembrane proteins. One group of putative channel proteins, including the abundant lens protein MIP, is widely distributed from prokaryotes to vertebrates. This article suggests that these proteins contain a structural twofold repeat and may have arisen by gene duplication. Such a model has implications for the tertiary structures of these important proteins.

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