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Eksp Klin Farmakol. 2006 Sep-Oct;69(5):16-9.

[Complex influence of pharmacological agents on degenerative processes in brain of Drosophila melanogaster mutants].

[Article in Russian]

Abstract

A scheme of complex administration of drugs in the order neuroprotector + neuroactivator + neuroretarder for the treatment of neurodegenerative processes in the brain has been elaborated and tested on a model object representing neurodegenerative mutants of Drosophila melanogaster. The appearance of changes in the brain was delayed when drugs were used separately: donepezil hydrochloride (arisept), 10 - 11 days, epinephrine and nimodipine, 1 - 2 days. The treatment of flies with the same drugs in the order arisept + epinephrine + nimodipine leads to the complete regeneration of D. melanogaster brain tissue to within 15 days of imago life.

PMID:
17153959
[Indexed for MEDLINE]

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