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Lupus. 2006;15(11):791-3.

Environment versus genetics in autoimmunity: a geneticist's perspective.

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  • 1Department of Internal Medicine/Rheumatology, University of Texas Southwestern Medical School, Dallas, TX 75390-8884, USA.


Both environmental as well as genetic factors have been documented to contribute to autoimmunity, as is evident from the accompanying articles in this journal. This raises an important question - which of these two elements plays a more important role in the genesis of autoimmunity? This report encapsulates a geneticist's perspective on this interesting question. Though lupus is used as an example in this essay, the proposed model is envisaged to operate in other autoimmune diseases as well.

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