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Med Phys. 2006 Nov;33(11):4176-83.

Mesh adaptation technique for Fourier-domain fluorescence lifetime imaging.

Author information

1
Department of Computer Science, University College London, Gower Street, London WC1E 6BT, United Kingdom. vadimsoloviev@yahoo.com

Abstract

A novel adaptive mesh technique in the Fourier domain is introduced for problems in fluorescence lifetime imaging. A dynamical adaptation of the three-dimensional scheme based on the finite volume formulation reduces computational time and balances the ill-posed nature of the inverse problem. Light propagation in the medium is modeled by the telegraph equation, while the lifetime reconstruction algorithm is derived from the Fredholm integral equation of the first kind. Stability and computational efficiency of the method are demonstrated by image reconstruction of two spherical fluorescent objects embedded in a tissue phantom.

PMID:
17153396
DOI:
10.1118/1.2362500
[Indexed for MEDLINE]
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