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Immunol Today. 1991 Jun;12(6):193-5.

The dominant self and the cryptic self: shaping the autoreactive T-cell repertoire.

Author information

1
Xenova Ltd, Slough, UK.

Abstract

Deletion of autoreactive T cells during the induction of self tolerance has been directly demonstrated. However, it is still relatively easy to detect self reactivity in normal healthy animals. In this article, Guy Gammon, Eli Sercarz and Gilles Benichou speculate on which T cells may escape tolerance induction and discuss how these cells could subsequently be involved in autoimmunity.

PMID:
1715167
DOI:
10.1016/0167-5699(91)90052-U
[Indexed for MEDLINE]

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