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Genetics. 2007 Mar;175(3):1267-74. Epub 2006 Dec 6.

Haplotype probabilities for multiple-strain recombinant inbred lines.

Author information

1
Research Unit Genetics and Biometry, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany.

Abstract

Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabilities for 2(n)-way RIL; the former required hefty computation to infer the symbolic results, and the latter were strictly numerical. We describe a simpler approach for the calculation of these probabilities, which allowed us to derive the symbolic form of the three-point haplotype probabilities. We also extend the two-point results for the case of additional generations of intermating, including the case of 2(n)-way intermated recombinant inbred populations (IRIP).

PMID:
17151250
PMCID:
PMC1840090
DOI:
10.1534/genetics.106.064063
[Indexed for MEDLINE]
Free PMC Article
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