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Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.

Author information

1
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.

Abstract

Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.

PMID:
17150656
DOI:
10.1093/nass/49.1.107
[Indexed for MEDLINE]

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