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Development of potent and selective human A3 adenosine receptor agonists.

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1
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.

Abstract

On the basis of bioisosteric rationale, structure-activity relationship of Cl-IB-MECA, which showed high binding affinity at the human A3 adenosine receptor, was studied. From this study, 2-chloro-4'-thioadenosine-5'-methyluronamide was discovered as the most potent and selective agonist at the human A3 adenosine receptor.

PMID:
17150618
DOI:
10.1093/nass/49.1.31
[Indexed for MEDLINE]
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