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Genome Biol. 2006;7(11):120.

How complete are current yeast and human protein-interaction networks?

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1
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.

Abstract

We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.

PMID:
17147767
PMCID:
PMC1794583
DOI:
10.1186/gb-2006-7-11-120
[Indexed for MEDLINE]
Free PMC Article
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