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Oncogene. 2007 May 24;26(24):3582-6. Epub 2006 Dec 4.

E-cadherin repression contributes to c-Myc-induced epithelial cell transformation.

Author information

1
Department of Pharmacology, Dartmouth Medical School, Norris Cotton Cancer Center, Lebanon, NH 03756, USA.

Abstract

c-Myc oncoprotein is overexpressed in a significant proportion of human epithelial cancers, and experimental overexpression of c-Myc in epithelial cells promotes tumour formation. However, it is not known how c-Myc promotes epithelial cell tumour formation. We report that c-Myc expression in human mammary epithelial cells induces a dramatic change in cell morphology, with some characteristics of an 'epithelial to mesenchymal transition'. E-cadherin expression is repressed by a post-transcriptional mechanism in cells expressing c-Myc. Furthermore, E-cadherin repression is necessary for c-Myc-induced cell transformation.

PMID:
17146437
DOI:
10.1038/sj.onc.1210132
[Indexed for MEDLINE]

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